81944-08-3

81944-08-3 structure

Name: (E)-Ligustilide
Chemical Name: trans-ligustilide
CAS Number: 81944-08-3
Molecular Formula: C₁₂H₁₄O₂
Molecular Weight: 190.23800
Catalog: Research Areas Metabolic Disease
Create Date: 2018-05-17 02:47:54
Modify Date: 2024-01-10 12:24:26
(E)-Ligustilide is isolated from Angelica sinensis and has nephroprotective effects[1]。

Name	trans-ligustilide
Synonyms	E-ligustilide 3-But-(E)-ylidene-4,5-dihydro-3H-isobenzofuran-1-one (E)-Ligustilide

Description	(E)-Ligustilide is isolated from Angelica sinensis and has nephroprotective effects[1]。
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	(E)-Ligustilide (50 μM; 24-72 hours) decreases HK-2 cell survival to 86%, to 67% and to 49% for 24, 48 or 72 hours incubation, respectively[1]. (E)-Ligustilide (50 μM; 48-72 hours) alone decreases the metabolic activity to 87±6% and 71±8% after 48 and 72 h incubation, respectively, as compared to the control condition in HK-2 cells[1]. Cell Viability Assay[1] Cell Line: HK-2 cell Concentration: 50 μM Incubation Time: 24 hours, 48 hours and 72 hours Result: Decreased cell survival as a dose-dependent manner.
References	[1]. Bunel V, et al. Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro.Toxicol In Vitro. 2015 Apr;29(3):458-67.