151978-50-6

151978-50-6 structure
151978-50-6 structure
  • Name: tert-Butyl pent-4-yn-1-ylcarbamate
  • Chemical Name: N-Boc-4-pentyne-1-amine
  • CAS Number: 151978-50-6
  • Molecular Formula: C10H17NO2
  • Molecular Weight: 183.24700
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2016-09-08 10:35:12
  • Modify Date: 2024-01-11 11:15:14
  • N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122)[1].

Name N-Boc-4-pentyne-1-amine
Synonyms tert-butyl N-pent-4-ynylcarbamate
Description N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122)[1].
Related Catalog
Target

Alkyl-Chain

References

[1]. Yang J, et al. Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. J Med Chem. 2019 Oct 21.

Molecular Formula C10H17NO2
Molecular Weight 183.24700
Exact Mass 183.12600
PSA 41.82000
LogP 2.12890
Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Hazard Codes C
RIDADR UN 2735PSN1 8 / PGII
HS Code 2924199090

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Literature: WO2013/96771 A1, ; Page/Page column 215 ;

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Literature: Synthesis, , # 9 art. no. Z17611SS, p. 1477 - 1483

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Literature: Organic Letters, , vol. 9, # 15 p. 2887 - 2889

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Literature: US2011/152321 A1, ;

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151978-50-6 structure

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Literature: WO2013/96771 A1, ;

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151978-50-6 structure

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Literature: WO2013/96771 A1, ;
HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%