83843-39-4

83843-39-4 structure

Name: GYKI-23107
Chemical Name: 1-N-(2,6-dimethylphenyl)-2-N,2-N-dimethylpropane-1,2-diamine,dihydrochloride
CAS Number: 83843-39-4
Molecular Formula: C₁₃H₂₄Cl₂N₂
Molecular Weight: 279.24900
Create Date: 2016-02-27 17:36:33
Modify Date: 2023-10-21 20:15:55
GYKI-23107 is an antiarrhythmic agent with local anaesthetic activity. GYKI-23107 was effective against chemically (aconitine and ouabain) induced arrhythmias after both parenteral and oral administration. GYKI-23107 and mexiletine produced similar elevation of the fibrillation threshold in anaesthetized cats. After oral pretreatment, GYKI-23107 showed protective effects against coronary ligation-induced arrhythmia in conscious rats. The circulatory side-effects of GYKI-23107 in anaesthetized and conscious dogs and cats were milder then those of mexiletine.

Name	1-N-(2,6-dimethylphenyl)-2-N,2-N-dimethylpropane-1,2-diamine,dihydrochloride

CHEMICAL NAME :: 1,2-Propanediamine, N(sup 2),N(sup 2)-dimethyl-N(sup 1)-2,6-xylyl-, dihydrochloride

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987