56049-88-8
56049-88-8 structure
- Name: MK196
- Chemical Name: (+/-)-Indacrinone
- CAS Number: 56049-88-8
- Molecular Formula: C18H14Cl2O4
- Molecular Weight: 365.20700
- Catalog: Research Areas Metabolic Disease
- Create Date: 2018-01-14 14:55:21
- Modify Date: 2024-01-10 16:18:04
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MK196 (MK-196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.
| Name | (+/-)-Indacrinone |
|---|---|
| Synonyms |
(6,7-Dichloro-2-methyl-1-oxo-2-phenyl-indan-5-yloxy)-acetic acid
<(6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyl)oxy>acetic acid indacrinone (1-oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy) acetic acid [(6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyl)-oxy]-acetic acid (1-oxo-2-phenyl-2-methyl-6,7-dichloro-5-indanyloxy)-acetic acid (6,7 dichloro 2 methyl 1 oxo 2 phenylindan 5 yloxy)acetic acid [(6,7-Dichloro-2,3-Dihydro-2-Methyl-1-Oxo-2-Phenyl-1H-Inden-5-Yl)Oxy]Acetic Acid MK196 |
| Description | MK196 (MK-196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee. |
|---|---|
| Related Catalog | |
| In Vivo | As the dose increasing from 1 to 10 mg/kg, the amount excreted via the urine decreased from 20 to 11% of administered dose. The amount excretes via the feces is 2-fold higher at the lower dose. At the 10 mg/kg dose the MK-196/1 ratio was 0.8 and 5 for the urine and feces, respectively. The urinary ratio of MK-196/1 decrease as dose increasing from 10 mg/kg (0.5) to 20 mg/kg (0.2)[1]. |
| Animal Admin | Sixteen mice are administered MK-196-14C. Four mice, 2 male and 2 female, are dosed orally with 10 mg/kg of drug and four additional mice (2M, 2F) are given the drug i.v. via the tail vein. In similar fashion eight additional mice are dosed with 1 mg/kg MK-196-14C either orally or intravenously.The animals are housed in separate metabolism cages, 2 mice of same sex per cage.The animals are fasted overnight prior to drug administration. Urine and feces are collected for the 24-hour period post drug. Animals are allowed free access to water. Urine specimens are also obtained from mice which receive MK-196 orally at doses of 10 and 20 mg/kg/day for 9 days. On day 9 the mice are dosed and placed in metabolism cages; two cages are used per sex per group. Urine is collected during the five-hour period post last dose. A total of nineteen mice are dosed with 10 mg/kg and 18 mice are dosed with 20 mg/kg of drug[1]. |
| References |
| Density | 1.423g/cm3 |
|---|---|
| Boiling Point | 553.63°C at 760 mmH |
| Molecular Formula | C18H14Cl2O4 |
| Molecular Weight | 365.20700 |
| Flash Point | 288.625°C |
| Exact Mass | 364.02700 |
| PSA | 63.60000 |
| LogP | 4.15350 |