22860-72-6

22860-72-6 structure

Name: Pedaliin
Chemical Name: 7-methoxyluteolin-6-C-β-D-glucopyranoside
CAS Number: 22860-72-6
Molecular Formula: C₂₂H₂₂O₁₂
Molecular Weight: 478.40300
Catalog: Research Areas Cancer
Create Date: 2018-04-13 18:04:06
Modify Date: 2024-01-18 14:10:56
Pedaliin is a bioactive component obtained from the ethanol extract of Sesame (Sesamum indicum L.) leaves (SLs). Pedaliin shows in vitro antioxidant and anti-colon cancer efficacy with radical scavenging activity and ferric reducing antioxidant power (FRAP)[1][2].

Name	7-methoxyluteolin-6-C-β-D-glucopyranoside
Synonyms	pedalitin-6-O-glucoside Pedaliin 2-(3,4-Dihydroxy-phenyl)-5-hydroxy-7-methoxy-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-chromen-4-one pedalitin 6-O-β-D-glucopyranoside Methyleugenol

Description	Pedaliin is a bioactive component obtained from the ethanol extract of Sesame (Sesamum indicum L.) leaves (SLs). Pedaliin shows in vitro antioxidant and anti-colon cancer efficacy with radical scavenging activity and ferric reducing antioxidant power (FRAP)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Pedaliin (0-35 μM; 72 h) dose-dependently attenuates the growth of human colon cancer cells, HT29 and HCT116[1]. Pedaliin (3.5-35 μM; 30 min; 37 ℃) has ferric reducing antioxidant power (FRAP)[1]. Pedaliin (7 μM; 48 h) alleviates invasion and migration of HT29 and HCT116 cells in non-cytotoxic conditions[1]. Pedaliin (20 μL) shows high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, oxygen radical absorbance capacity (ORAC), and in vitro antiglycation activities, and inhibits BSA glycation with an IC50 value of 41.8 μM[2]. Cell Viability Assay[1] Cell Line: HCT116 cells Concentration: 0, 3.5, 7, 17.5, and 35 μM Incubation Time: 48 hours or 72 hours Result: Inhibited cell growth (72 h) by 24% at 3.5-35 µM, invasion (48 h) by 18% at 7 µM, and migration (48 h) by 33% at 7 µM.