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52435-06-0

52435-06-0 structure
52435-06-0 structure
  • Name: leuprolide IS
  • Chemical Name: leuprolide IS
  • CAS Number: 52435-06-0
  • Molecular Formula: C56H78N16O12
  • Molecular Weight: 1167.32000
  • Catalog: Biochemical Amino acids and their derivatives Alanine derivatives
  • Create Date: 2018-02-19 04:05:56
  • Modify Date: 2024-06-08 16:10:55
  • (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility[1][2][3].
Name leuprolide IS
Synonyms alarelin
pGlu-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHC2H5
Description (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility[1][2][3].
Related Catalog
In Vitro (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH 用作醋酸亮丙瑞林的内标[1] (1) 100 µL 血浆样品中加入 10 µL 200 ng/mL (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH 溶液。 (2) 冰冻的乙腈分两次 (每次 500 µL) 加入 (1) 中溶液。 (3) 2500 rpm 搅拌 10 min。 (4) 12500 rpm (4℃) 离心 10 min。 (5) 将上清液转移到离心管中，35℃、氮气下干燥，最后加入 100 µL 0.1% 甲酸水溶液/乙腈: 90/10 (v/v) 溶液。 (6) Thermo Scientific Vanquish UPLC 系统连接到 Thermo Scientific Orbitrap Exploris 480 质谱仪。用 Waters Acquity UPLC HSS T3 色谱柱 (2.1 × 100 mm，1.8 µm) 在温度为 40℃ 下分离。 (7) 流动相 A 为 0.1% 甲酸水溶液，流动相 B 为 0.1% 甲酸乙腈溶液。梯度从 95% 流动相 A 开始，在 5 min 内降至 10%，然后保持恒定 0.5 min。6 min 时，色谱柱回到 95% 流动相 A，重新平衡 2 min。流速为 0.3 mL/min，注射体积为 20 µL。 (8) 样品经 3500V 电喷雾电离，在正离子模式下 m/z 605.3275 为醋酸亮丙瑞林，m/z 584.3052 为内标。用 Xcalibur 软件 (4.4 版本) 分析数据。
In Vivo (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (2 µg/kg；腹腔注射；单剂量) 显著增加了去性腺和未去性腺的成年雄性大鼠焦虑行为[2]。 (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (50 µg；单剂量) 当与 Ainil (3 mL/kg) 联用时，提高了母牛受精后的生育力并防止了胚胎死亡[3]。
References

[1]. Wan B, et al. Polymer source affects in vitro-in vivo correlation of leuprolide acetate PLGA microspheres. Int J Pharm. 2022 Sep 25;625:122032.  

[2]. Masalova OO, et al. Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats. Bull Exp Biol Med. 2019 Nov;168(1):52-54.  

[3]. Kraevskiy A Y, et al. Surfagon and Ketaprofen for increasing fertility and preventing embryonic death in cows after insemination AY[J]. Ukrainian Journal of Ecology, 2020, 10(4): 159-164.

Molecular Formula C56H78N16O12
Molecular Weight 1167.32000
Exact Mass 1166.60000
PSA 429.04000
LogP 2.33020
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