144449-71-8

144449-71-8 structure

Name: Dofetilide N-oxide
Chemical Name: Dofetilide N-oxide
CAS Number: 144449-71-8
Molecular Formula: C₁₉H₂₇N₃O₆S₂
Molecular Weight: 457.56400
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-04-15 05:57:03
Modify Date: 2025-08-27 16:12:32
Dofetilide N-oxide (UK-116856) is a metabolite of Dofetilide. Dofetilide is a class III antiarrhythmic agent that blocks potassium channels[1][2].

Name	Dofetilide N-oxide
Synonyms	N-[4-(2-{[2-(4-methanesulfonylamino-phenyl)-ethyl]-methyl-amino}-ethoxy)-phenyl]-methanesulfonamide N-oxide

Description	Dofetilide N-oxide (UK-116856) is a metabolite of Dofetilide. Dofetilide is a class III antiarrhythmic agent that blocks potassium channels[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	Potassium channels[1][2]
References	[1]. Maisch B, et al. Pregnancy and cardiomyopathies. Herz. 2003 May;28(3):196-208. [2]. Snyders, D.J. and A. Chaudhary, High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol, 1996. 49(6): p. 949-55.