1048668-70-7
1048668-70-7 structure
- Name: AZD8329
- Chemical Name: 4-[4-(1-adamantylcarbamoyl)-5-tert-butylpyrazol-1-yl]benzoic acid
- CAS Number: 1048668-70-7
- Molecular Formula: C25H31N3O3
- Molecular Weight: 421.53200
- Catalog: Research Areas Metabolic Disease
- Create Date: 2017-02-17 22:23:50
- Modify Date: 2024-01-13 15:51:55
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AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3[1].
| Name | 4-[4-(1-adamantylcarbamoyl)-5-tert-butylpyrazol-1-yl]benzoic acid |
|---|---|
| Synonyms | unii-5b38cv1212 |
| Description | AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3[1]. |
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| Related Catalog | |
| Target |
IC50: 9 nM (Human 11β-HSD1)[1] |
| In Vitro | AZD8329 shows IC50s of 0.009, 0.0086, 0.008, 0.024, 0.002 and 6.1 μM for human enzyme, rat enzyme, dog enzyme, cyno enzyme, human adipocyte and mouse enzyme, respectively[1]. |
| References |
| Molecular Formula | C25H31N3O3 |
|---|---|
| Molecular Weight | 421.53200 |
| Exact Mass | 421.23700 |
| PSA | 87.71000 |
| LogP | 5.14140 |
|
~89%
1048668-70-7 |
| Literature: Scott, James S.; Deschoolmeester, Joanne; Kilgour, Elaine; Mayers, Rachel M.; Packer, Martin J.; Hargreaves, David; Gerhardt, Stefan; Ogg, Derek J.; Rees, Amanda; Selmi, Nidhal; Stocker, Andrew; Swales, John G.; Whittamore, Paul R.O. Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10136 - 10147 |
|
~%
1048668-70-7 |
| Literature: Scott, James S.; Deschoolmeester, Joanne; Kilgour, Elaine; Mayers, Rachel M.; Packer, Martin J.; Hargreaves, David; Gerhardt, Stefan; Ogg, Derek J.; Rees, Amanda; Selmi, Nidhal; Stocker, Andrew; Swales, John G.; Whittamore, Paul R.O. Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10136 - 10147 |
| Precursor 2 | |
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| DownStream 0 | |