147912-03-6

147912-03-6 structure

Name: m-PEG4-O-NHS ester
Chemical Name: 11-methoxy-3,6,9-trioxaundecanyl N-succinimidyl carbonate
CAS Number: 147912-03-6
Molecular Formula: C₁₄H₂₃NO₉
Molecular Weight: 349.33400
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-04-07 10:45:51
Modify Date: 2024-01-30 17:24:09
m-PEG4-O-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	11-methoxy-3,6,9-trioxaundecanyl N-succinimidyl carbonate
Synonyms	carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethyl ester

Description	m-PEG4-O-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562