259886-51-6

259886-51-6 structure

Name: CUCURBIT(8)URIL
Chemical Name: cucurbit[8]uril
CAS Number: 259886-51-6
Molecular Formula: C₄₈H₄₈N₃₂O₁₆
Molecular Weight: 1329.10
Catalog: Catalysts and additives polymer
Create Date: 2018-07-14 23:06:26
Modify Date: 2024-01-02 10:09:49
Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy transfer [1][2].

Name	cucurbit[8]uril
Synonyms	CB8 Q[8] curcurbit[8]uril MFCD03456501 cucurbituril[8] CB[8]

Description	Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy transfer [1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	Protein Heterodimerization[1]
In Vitro	Cucurbit[8]uril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%[2]. Cucurbit[8]uril indeed selectively induces the heterodimerization of MV–eYFP with Np–eCFP. Cucurbit[8]uril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbit[8]uril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbit[8]uril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbit[8]uril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces[1]. Cell Viability Assay[1] Cell Line: CHO-K1 cells Concentration: 0~20 μM Incubation Time: 48 hours Result: At the highest investigated concentration of 20 μM after 48 h, the relative cell viability dropped marginally to 86%.
In Vivo	Cucurbit[8]uril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice[2].
References	[1]. Uhlenheuer DA, et al. Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins. Chem Commun (Camb). 2011;47(24):6798-6800. [2]. Uzunova VD, et al. Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study. Org Biomol Chem. 2010;8(9):2037-2042.

Density	2.71
Molecular Formula	C₄₈H₄₈N₃₂O₁₆
Molecular Weight	1329.10
Exact Mass	1328.39000
PSA	376.80000
Appearance	solid \| white

WGK Germany	3

259886-51-6	259886-49-2
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111830-52-5	41098-99-1
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