CUCURBIT(8)URIL

Modify Date: 2024-01-02 10:09:49

CUCURBIT(8)URIL Structure
CUCURBIT(8)URIL structure
 Common Name CUCURBIT(8)URIL
CAS Number 259886-51-6 Molecular Weight 1329.10
Density 2.71 Boiling Point N/A
Molecular Formula C48H48N32O16 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CUCURBIT(8)URIL


Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy transfer [1][2].

 Names

Name cucurbit[8]uril
Synonym More Synonyms

 CUCURBIT(8)URIL Biological Activity

Description Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy transfer [1][2].
Related Catalog
Target

Protein Heterodimerization[1]

In Vitro Cucurbit[8]uril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%[2]. Cucurbit[8]uril indeed selectively induces the heterodimerization of MV–eYFP with Np–eCFP. Cucurbit[8]uril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbit[8]uril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbit[8]uril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbit[8]uril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces[1]. Cell Viability Assay[1] Cell Line: CHO-K1 cells Concentration: 0~20 μM Incubation Time: 48 hours Result: At the highest investigated concentration of 20 μM after 48 h, the relative cell viability dropped marginally to 86%.
In Vivo Cucurbit[8]uril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice[2].
References

[1]. Uhlenheuer DA, et al. Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins. Chem Commun (Camb). 2011;47(24):6798-6800.

[2]. Uzunova VD, et al. Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study. Org Biomol Chem. 2010;8(9):2037-2042.

 Chemical & Physical Properties

Density 2.71
Molecular Formula C48H48N32O16
Molecular Weight 1329.10
Exact Mass 1328.39000
PSA 376.80000
Appearance of Characters solid | white

 Safety Information

WGK Germany 3

 Synonyms

CB8
Q[8]
curcurbit[8]uril
MFCD03456501
cucurbituril[8]
CB[8]
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