195615-84-0
195615-84-0 structure
- Name: AN2/AVex-73 hydrochloride salt
- Chemical Name: 1-(2,2-Diphenyltetrahydro-3-furanyl)-N,N-dimethylmethanamine hydrochloride (1:1)
- CAS Number: 195615-84-0
- Molecular Formula: C19H24ClNO
- Molecular Weight: 317.853
- Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
- Create Date: 2018-04-18 12:16:44
- Modify Date: 2024-01-09 23:06:54
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AVex-73 hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM.
| Name | 1-(2,2-Diphenyltetrahydro-3-furanyl)-N,N-dimethylmethanamine hydrochloride (1:1) |
|---|---|
| Synonyms |
1-(2,2-Diphenyltetrahydro-3-furanyl)-N,N-dimethylmethanaminhydrochlorid (1:1)
3-Furanmethanamine, tetrahydro-N,N-dimethyl-2,2-diphenyl-, hydrochloride (1:1) 1-(2,2-Diphényltétrahydro-3-furanyl)-N,N-diméthylméthanamine, chlorhydrate (1:1) 1-(2,2-Diphenyltetrahydro-3-furanyl)-N,N-dimethylmethanamine hydrochloride (1:1) Anavex 2-73 AVex-73 hydrochloride |
| Description | AVex-73 hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 860 nM (Sigma-1 Receptor)[1] |
| In Vivo | The pre-administration of AVex-73 hydrochloride (ANAVEX2-73) leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with AVex-73 hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg[1]. The AVex-73 hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1 mg/kg. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by AVex-73 hydrochloride at 0.1 and 1 mg/kg dose. Seven days after injections,AVex-73 hydrochloride attenuates the decrease in Ser9 phosphorylation induced by the peptide at 0.3 and 1 mg/kg. The AVex-73 hydrochloride treatment dose-dependently prevents the Aβ25-35-induced increase in Aβ1-42 content, with a significant effect at the highest dose tested[2]. |
| Animal Admin | Male mice aged 7-9 weeks and weighing 32±2 g are used. Drugs (including AVex-73 hydrochloride) are brought up to each dose by dilution and injected in a volume of 100 μL/20 g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures[2]. |
| References |
| Molecular Formula | C19H24ClNO |
|---|---|
| Molecular Weight | 317.853 |
| Exact Mass | 317.154633 |
| Storage condition | -20℃ |