84783-01-7

84783-01-7 structure

Name: K-Ras-IN-1
Chemical Name: 1-[(2-Hydroxyphenyl)thioxomethyl]pyrrolidine
CAS Number: 84783-01-7
Molecular Formula: C₁₁H₁₃NOS
Molecular Weight: 207.292
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2018-02-01 13:25:03
Modify Date: 2024-01-08 18:35:22
K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.(the detailed information refer to the reference)

Name	1-[(2-Hydroxyphenyl)thioxomethyl]pyrrolidine
Synonyms	(2-Hydroxyphenyl)(1-pyrrolidinyl)methanethione 1-[(2-Hydroxyphenyl)thioxomethyl]pyrrolidine (2-Hydroxyphenyl)(1-pyrrolidinyl)methanthion (2-Hydroxyphényl)(1-pyrrolidinyl)méthanethione Methanethione, (2-hydroxyphenyl)-1-pyrrolidinyl- K-Ras-IN-1

Description	K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.(the detailed information refer to the reference)
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Ras Research Areas >> Cancer
References	[1]. Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54(2):530-538. [2]. Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-6143