K-Ras-IN-1

Modify Date: 2024-01-08 18:35:22

K-Ras-IN-1 structure	Common Name	K-Ras-IN-1
	CAS Number	84783-01-7	Molecular Weight	207.292
	Density	1.3±0.1 g/cm3	Boiling Point	332.1±44.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₃NOS	Melting Point	N/A
	MSDS	N/A	Flash Point	154.7±28.4 °C

Use of K-Ras-IN-1

K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.(the detailed information refer to the reference)

Name	1-[(2-Hydroxyphenyl)thioxomethyl]pyrrolidine
Synonym	More Synonyms

Description	K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.(the detailed information refer to the reference)
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Ras Research Areas >> Cancer
References	[1]. Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54(2):530-538. [2]. Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-6143

Description

K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.(the detailed information refer to the reference)

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Ras

Research Areas >> Cancer

References

[1]. Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54(2):530-538.

[2]. Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-6143

Density	1.3±0.1 g/cm3
Boiling Point	332.1±44.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₃NOS
Molecular Weight	207.292
Flash Point	154.7±28.4 °C
Exact Mass	207.071777
LogP	2.06
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.668
Storage condition	2-8℃

(2-Hydroxyphenyl)(1-pyrrolidinyl)methanethione

1-[(2-Hydroxyphenyl)thioxomethyl]pyrrolidine

(2-Hydroxyphenyl)(1-pyrrolidinyl)methanthion

(2-Hydroxyphényl)(1-pyrrolidinyl)méthanethione

Methanethione, (2-hydroxyphenyl)-1-pyrrolidinyl-

K-Ras-IN-1

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China
Product Name: K-Ras-IN-1
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China
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: K-Ras-IN-1
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: K-Ras-IN-1
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: $462/10mM*1mLinDMSO

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K-Ras-IN-1

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