88039-46-7

88039-46-7 structure

Name: INF 4E
Chemical Name: ethyl 2-((2-chlorophenyl)(hydroxy)methyl)acrylate
CAS Number: 88039-46-7
Molecular Formula: C₁₂H₁₃ClO₃
Molecular Weight: 240.68300
Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
Create Date: 2018-02-12 23:30:20
Modify Date: 2025-08-26 10:54:04
INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction[1][2].

Name	ethyl 2-((2-chlorophenyl)(hydroxy)methyl)acrylate
Synonyms	2-[hydroxy(2-chlorophenyl)methyl]acrylic acid ethyl ester 2-[(2-Chloro-phenyl)-hydroxy-methyl]-acrylic acid ethyl ester

Description	INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
In Vitro	INF4E (compound 9) preventes both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent mannersup>[3].
In Vivo	INF4E significantly reduces the in infarct size and lactate dehydrogenase release and improvement in postischemic left ventricular pressure[1]. INF4E attenuates the formation of NLRP3 inflammasome complex was induced by myocardial IR (ischemia/reperfusion) in a time-dependent way[1].
References	[1]. Shi Y, et al. NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages. Int Immunopharmacol. 2021 Mar;92:107358. [2]. Mezzaroma E,et al. NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases. Molecules. 2021 Feb 12;26(4):976. [3]. occo M, et al. Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J Med Chem. 2014 Dec 26;57(24):10366-82.