18385-59-6

18385-59-6 structure

Name: Epoxyazadiradione
Chemical Name: epoxyazadiradione
CAS Number: 18385-59-6
Molecular Formula: C₂₈H₃₄O₆
Molecular Weight: 466.56600
Create Date: 2017-12-07 22:09:05
Modify Date: 2024-03-26 22:51:48
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (Ki, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human[1].

Name	epoxyazadiradione
Synonyms	ethyl 2,3-epoxybutyrate ethyl 2,3-epoxybutanoate Epoxyazadiradione 2,3-Epoxybutyric acid,ethyl ester epoxy-2,3 butanoate d'ethyle BUTYRIC ACID,2,3-EPOXY-,ETHYL ESTER 2,3-Epoxybuttersaeure-ethylester 3-methyl-oxiranecarboxylic acid ethyl ester

Description	Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (Ki, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human[1].
Related Catalog	Research Areas >> Infection
References	[1]. Alam A, et al. Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor. J Biol Chem. 2012;287(29):24844-24861.