936449-28-4

936449-28-4 structure

Name: PDE5-IN-42
Chemical Name: 1-[1-(2-ethoxy-ethyl)-3-ethyl-7-(4-methyl-pyridin-2-ylamino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-piperidine-4-carboxylic acid
CAS Number: 936449-28-4
Molecular Formula: C₂₃H₃₁N₇O₃
Molecular Weight: 453.53700
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2018-01-30 03:14:27
Modify Date: 2024-01-31 16:23:58
PDE5-IN-42 (Compound 42) is a potent and orally active PDE5 inhibitor with an IC50 of 0.04 nM. PDE5-IN-42 maintains selectivity over PDE6 and PDE11[1].

Name	1-[1-(2-ethoxy-ethyl)-3-ethyl-7-(4-methyl-pyridin-2-ylamino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-piperidine-4-carboxylic acid

Description	PDE5-IN-42 (Compound 42) is a potent and orally active PDE5 inhibitor with an IC50 of 0.04 nM. PDE5-IN-42 maintains selectivity over PDE6 and PDE11[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Target	IC50: 0.04 nM (PDE5)[1]
References	[1]. Tollefson MB, et al. 1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors. Bioorg Med Chem Lett. 2010 May 15;20(10):3120-4.