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85278-24-6

85278-24-6 structure
85278-24-6 structure
  • Name: MDL72274 HCl
  • Chemical Name: (E)-2-phenyl-3-chloroallylamine hydrochloride
  • CAS Number: 85278-24-6
  • Molecular Formula: C9H11Cl2N
  • Molecular Weight: 204.09600
  • Create Date: 2018-04-18 23:04:13
  • Modify Date: 2024-04-06 16:25:19
  • MDL-72274 HCl is selective and potent inhibitors of SSAO for treatment of Parkinson diseases. MDL-72974 is a potent (IC50 = 10(-9) M) inhibitor of both MAO-B and SSAO, with 190-fold lower affinity for MAO-A. In clinical studies, oral doses as low as 100 micrograms produced substantial inhibition of platelet MAO-B. One or 4 mg MDL-72274 HCl given daily for 28 days to 40 Parkinson's patients treated with L-dopa produced statistically significant reductions in the Unified Parkinson's Disease Rating Scale. MAO-B inhibitors, such as MDL 72974A and L-deprenyl, offer the potential of being neuroprotective in Parkinson's Disease and other neurogenerative disorders.

Name (E)-2-phenyl-3-chloroallylamine hydrochloride
Synonyms (E)-3-Chloro-2-phenyl-allylamine
hydrochloride
(E)-3-chloro-2-phenylallylamine hydrochloride
MDL72274 HCl
Molecular Formula C9H11Cl2N
Molecular Weight 204.09600
Exact Mass 203.02700
PSA 26.02000
LogP 3.72730
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