99119-73-0

99119-73-0 structure

Name: Kushenol C
Chemical Name: Kushenol C
CAS Number: 99119-73-0
Molecular Formula: C₂₅H₂₆O₇
Molecular Weight: 438.47000
Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
Create Date: 2018-05-31 08:00:00
Modify Date: 2024-01-17 18:20:04
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM[1][2].

Name	Kushenol C
Synonyms	kushenol C 2-(2,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-8-(2-isopropenyl-5-methyl-hex-4-enyl)-chromen-4-one

Description	Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Inflammation/Immunology
In Vitro	Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 µM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells[1]. Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells[1]. Kushenol C inhibits BChE and AChE with IC50s of 54.86 and 33.13 µM[2].
References	[1]. Cho BO, et al. In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophoraflavescens. Molecules. 2020;25(8):1768. Published 2020 Apr 12. [2]. Jung HA, et al. Selective inhibition of prenylated flavonoids from Sophora flavescens against BACE1 and cholinesterases. Am J Chin Med. 2010;38(2):415-429.

Molecular Formula	C₂₅H₂₆O₇
Molecular Weight	438.47000
Exact Mass	438.16800
PSA	131.36000
LogP	5.07910

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