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87424-26-8

87424-26-8 structure
87424-26-8 structure
  • Name: Thiocolchicine analog
  • Chemical Name: N-[(7S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
  • CAS Number: 87424-26-8
  • Molecular Formula: C21H23NO5S
  • Molecular Weight: 401.47600
  • Create Date: 2017-06-09 09:27:04
  • Modify Date: 2026-10-22 18:01:36
Name N-[(7S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Synonyms (S)-N-(2-Hydroxy-1,3-dimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalen-7-yl)acetamide
N-((S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
2-Demethyl Thiocolchicine
(S)-7-Acetylamino-2-hydroxy-1,3-dimethoxy-10-methylmercapto-6,7-dihydro-5H-benzo[a]heptalen-9-on
O(sup 2)-Demethyl-10-thiocolchicine
Acetamide, N-[(7S)-5,6,7,9-tetrahydro-2-hydroxy-1,3-dimethoxy-10-(methylthio)-9-oxobenzo[a]htalen-7-yl]
N-((S)-2-Hydroxy-1,3-dimethoxy-10-methylmercapto-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid
COLCHICINE,O(sup 2)-DEMETHYL-10-THIO
N-[(7S)-5,6,7,9-Tetrahydro-2-hydroxy-1,3-diMethoxy-10-(Methylthio)-9-oxobenzo[a]htalen-7-yl]acetaMide
Density 1.33g/cm3
Boiling Point 766.8ºC at 760 mmHg
Melting Point 218-220ºC
Molecular Formula C21H23NO5S
Molecular Weight 401.47600
Flash Point 417.6ºC
Exact Mass 401.13000
PSA 110.16000
LogP 3.67280
Index of Refraction 1.636

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0882000
CHEMICAL NAME :
Colchicine, O(sup 2)-demethyl-10-thio-
CAS REGISTRY NUMBER :
87424-26-8
BEILSTEIN REFERENCE NO. :
3176298
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H23-N-O5-S
MOLECULAR WEIGHT :
401.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25 ug/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
Precursor  3

DownStream  0

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