87424-26-8

• 常用中文名：2-脱甲基硫代秋水仙碱
• 常用英文名：Thiocolchicine analog
• CAS号：87424-26-8
• 分子式：C₂₁H₂₃NO₅S
• 分子量：401.47600
• 发布时间：2017-06-09 09:27:04
• 更新时间：2024-01-21 18:26:37

名称

• 中文名: 2-脱甲基硫代秋水仙碱
• 英文名: N-[(7S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• 英文别名: N-((S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide; N-((S)-2-Hydroxy-1,3-dimethoxy-10-methylmercapto-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid; 2-Demethyl Thiocolchicine; COLCHICINE,O(sup 2)-DEMETHYL-10-THIO; (S)-7-Acetylamino-2-hydroxy-1,3-dimethoxy-10-methylmercapto-6,7-dihydro-5H-benzo[a]heptalen-9-on; O(sup 2)-Demethyl-10-thiocolchicine

物化性质

• 密度: 1.33g/cm3
• 沸点: 766.8ºC at 760 mmHg
• 熔点: 218-220ºC
• 分子式: C₂₁H₂₃NO₅S
• 分子量: 401.47600
• 闪点: 417.6ºC
• 精确质量: 401.13000
• PSA: 110.16000
• LogP: 3.67280
• 折射率: 1.636

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0882000 CHEMICAL NAME : Colchicine, O(sup 2)-demethyl-10-thio- CAS REGISTRY NUMBER : 87424-26-8 BEILSTEIN REFERENCE NO. : 3176298 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C21-H23-N-O5-S MOLECULAR WEIGHT : 401.51 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 25 ug/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

合成路线

2730-71-4 ~3% 87424-26-8 51296-12-9 51296-11-8

文献：Guan, Jian; Brossi, Arnold; Zhu, Xiao-Kang; Wang, Hui-Kang; Lee, Kuo-Hsiung Synthetic Communications, 1998 , vol. 28, # 9 p. 1585 - 1591

51296-12-9 18107-18-1 ~% 87424-26-8 87424-25-7

文献：Nakagawa-Goto, Kyoko; Chen, Cyril X.; Hamel, Ernest; Wu, Chin-Chung; Bastow, Kenneth F.; Brossi, Arnold; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 235 - 238

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