1003878-07-6

1003878-07-6 structure

Name: GSK 1562590 hydrochloride
Chemical Name: 4'-[(1R)-1-{[(6,7-Dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino}-2-(1-pyrrolidinyl)ethyl]-3-biphenylcarboxamide hydrochloride (1:1)
CAS Number: 1003878-07-6
Molecular Formula: C₃₀H₃₁Cl₃N₄O₄
Molecular Weight: 617.95
Catalog: Signaling Pathways GPCR/G Protein Urotensin Receptor
Create Date: 2018-06-14 06:27:28
Modify Date: 2022-11-21 16:56:19
GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT[1].

Name	4'-[(1R)-1-{[(6,7-Dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino}-2-(1-pyrrolidinyl)ethyl]-3-biphenylcarboxamide hydrochloride (1:1)
Synonyms	4H-1,4-Benzoxazine-4-acetamide, N-[(1R)-1-[3'-(aminocarbonyl)[1,1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-, hydrochloride (1:1) 4'-[(1R)-1-{[(6,7-Dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino}-2-(1-pyrrolidinyl)ethyl]-3-biphenylcarboxamide hydrochloride (1:1)

Description	GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Urotensin Receptor
References	[1]. Behm DJ, et, al. GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo. Br J Pharmacol. 2010 Sep;161(1):207-28.