1276197-46-6

1276197-46-6 structure

Name: (rac)-Etodolac-d3
Chemical Name: {8-Ethyl-1-[(2,2,2-2H3)ethyl]-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl}acetic acid
CAS Number: 1276197-46-6
Molecular Formula: C₁₇H₁₈D₃NO₃
Molecular Weight: 290.372
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-02-02 21:09:20
Modify Date: 2024-01-05 17:09:55
(Rac)-Etodolac-d3 ((Rac)-AY-24236-d3) is a labelled racemic Etodolac. Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM)

Name	{8-Ethyl-1-[(2,2,2-2H3)ethyl]-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl}acetic acid
Synonyms	{8-Ethyl-1-[(2,2,2-H)ethyl]-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl}acetic acid Pyrano[3,4-b]indole-1-acetic acid, 8-ethyl-1-(ethyl-2,2,2-d)-1,3,4,9-tetrahydro-

Description	(Rac)-Etodolac-d3 ((Rac)-AY-24236-d3) is a labelled racemic Etodolac. Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM)
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [3]. Ito S, Tajima K, Nogawa M et al. Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. J Pharmacol Exp Ther. 2012 Jul;342(1):53-60. [4]. Yanaoka K, Oka M, Yoshimura N et al. Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion. Int J Cancer. 2010 Mar 15;126(6):1467-73. [5]. Matsuyama M, Yoshimura R, Hase T et al. Administration of the selective cyclooxygenase (COX)-2 inhibitor etodolac prolongs cardiac allograft survival in a mouse model. Mol Med Report. 2010 Sep-Oct;3(5):771-4.

Density	1.2±0.1 g/cm3
Boiling Point	507.9±45.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₈D₃NO₃
Molecular Weight	290.372
Flash Point	261.0±28.7 °C
Exact Mass	290.170959
LogP	3.59
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.597

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