1219798-68-1

1219798-68-1 structure

Name: 3-Methylglutaric acid-d4
Chemical Name: 3-Methylglutarate
CAS Number: 1219798-68-1
Molecular Formula: C₆H₁₀O₄
Molecular Weight: 146.141
Catalog: Research Areas Metabolic Disease
Create Date: 2018-06-03 19:39:47
Modify Date: 2024-01-01 21:10:19
3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].

Name	3-Methylglutarate
Synonyms	β-Methylglutaric acid b-methyl-Glutaric acid 3-methyl-Glutaric acid 3-Methylglutaric acid Pentanedioic acid, 3-methyl- β-methyl-Glutaric acid 3-Methylglutarate 3-Methylpentanedioic acid b-Methylglutaric acid 2-Methylglutaric acid

Description	3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Barich DH, et al. 3-Methylglutaric acid as a 13C solid-state NMR standard. Solid State Nucl Magn Reson. 2006 Oct;30(3-4):125-9. [3]. Dylan E Jones, et al. 3-Methylglutaric acid in energy metabolism. Clin Chim Acta. 2020 Mar;502:233-239.