1251752-12-1
1251752-12-1 structure
- Name: Bayer-18
- Chemical Name: 1-[3-({5-Fluoro-4-[(1-hydroxy-2-methyl-2-propanyl)amino]-2-pyrimidinyl}amino)phenyl]-3-(2-methyl-2-propanyl)urea
- CAS Number: 1251752-12-1
- Molecular Formula: C19H27FN6O2
- Molecular Weight: 390.455
- Create Date: 2018-01-16 08:19:02
- Modify Date: 2024-09-10 10:37:42
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Bayer-18 is a selective TYK2 inhibitor, with an IC50 of 18.7nM on TYK2 as measured by TYK2 HTRF assays.
| Name | 1-[3-({5-Fluoro-4-[(1-hydroxy-2-methyl-2-propanyl)amino]-2-pyrimidinyl}amino)phenyl]-3-(2-methyl-2-propanyl)urea |
|---|---|
| Synonyms |
Urea, N-(1,1-dimethylethyl)-N'-[3-[[5-fluoro-4-[(2-hydroxy-1,1-dimethylethyl)amino]-2-pyrimidinyl]amino]phenyl]-
1-[3-({5-Fluoro-4-[(1-hydroxy-2-methyl-2-propanyl)amino]-2-pyrimidinyl}amino)phenyl]-3-(2-methyl-2-propanyl)urea |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C19H27FN6O2 |
| Molecular Weight | 390.455 |
| Exact Mass | 390.217957 |
| LogP | 1.85 |
| Index of Refraction | 1.632 |