182755-41-5

182755-41-5 structure

Name: L-Homocystine-d8
Chemical Name: (2S)-2-(2H2)Amino-4-{[3-amino-3-carboxy(1-2H1)propyl]disulfanyl}(2H5)butanoic acid
CAS Number: 182755-41-5
Molecular Formula: C₈H₈D₈N₂O₄S₂
Molecular Weight: 276.40
Create Date: 2018-04-19 10:32:47
Modify Date: 2024-01-17 12:01:12
L-Homocystine-d8 is the deuterium labeled L-Homocystine. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.

Name	(2S)-2-(2H2)Amino-4-{[3-amino-3-carboxy(1-2H1)propyl]disulfanyl}(2H5)butanoic acid
Synonyms	(2S)-2-(H)Amino-4-{[3-amino-3-carboxy(1-H)propyl]disulfanyl}(H)butanoic acid Butanoic-2,3,3,4,4-d acid, 2-(amino-d)-4-[(3-amino-3-carboxypropyl-1-d)dithio]-, (2S)-

Description	L-Homocystine-d8 is the deuterium labeled L-Homocystine. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Padmanabhan R, et al. Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. Eur J Nutr. 2006 Sep;45(6):311-9