L-Homocystine-d8

Modify Date: 2024-01-17 12:01:12

L-Homocystine-d8 Structure
L-Homocystine-d8 structure
Common Name L-Homocystine-d8
CAS Number 182755-41-5 Molecular Weight 276.40
Density 1.4±0.1 g/cm3 Boiling Point 507.6±50.0 °C at 760 mmHg
Molecular Formula C8H8D8N2O4S2 Melting Point N/A
MSDS N/A Flash Point 260.8±30.1 °C

 Use of L-Homocystine-d8


L-Homocystine-d8 is the deuterium labeled L-Homocystine. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.

 Names

Name (2S)-2-(2H2)Amino-4-{[3-amino-3-carboxy(1-2H1)propyl]disulfanyl}(2H5)butanoic acid
Synonym More Synonyms

 L-Homocystine-d8 Biological Activity

Description L-Homocystine-d8 is the deuterium labeled L-Homocystine. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Padmanabhan R, et al. Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. Eur J Nutr. 2006 Sep;45(6):311-9

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 507.6±50.0 °C at 760 mmHg
Molecular Formula C8H8D8N2O4S2
Molecular Weight 276.40
Flash Point 260.8±30.1 °C
Exact Mass 276.105347
LogP 1.03
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.619

 Synonyms

(2S)-2-(H)Amino-4-{[3-amino-3-carboxy(1-H)propyl]disulfanyl}(H)butanoic acid
Butanoic-2,3,3,4,4-d acid, 2-(amino-d)-4-[(3-amino-3-carboxypropyl-1-d)dithio]-, (2S)-