616884-63-0

616884-63-0 structure

Name: OMDM-2
Chemical Name: (9Z)-N-[(2R)-1-Hydroxy-3-(4-hydroxyphenyl)-2-propanyl]-9-octadecenamide
CAS Number: 616884-63-0
Molecular Formula: C₂₇H₄₅NO₃
Molecular Weight: 431.651
Catalog: Research Areas Neurological Disease
Create Date: 2018-04-20 03:53:50
Modify Date: 2024-01-10 20:14:49
OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a Ki of 3.0 μM[1].

Name	(9Z)-N-[(2R)-1-Hydroxy-3-(4-hydroxyphenyl)-2-propanyl]-9-octadecenamide
Synonyms	(9Z)-N-[(2R)-1-Hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide 9-Octadecenamide, N-[(1R)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, (9Z)- (9Z)-N-[(2R)-1-Hydroxy-3-(4-hydroxyphenyl)-2-propanyl]-9-octadecenamide

Description	OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a Ki of 3.0 μM[1].
Related Catalog	Research Areas >> Neurological Disease
Target	Ki: 3.0 μM (anandamide cellular uptake)[1]
In Vitro	OMDM-2 shows poor affinity for either CB1 (Ki=5.1 μM) or CB2 (Ki>10 μM) receptors in rat brain and spleen membranes, respectively; OMDM-2 has almost no activity at vanilloid receptors in the intracellular calcium assay carried out with intact cells over-expressing the human VR1 (EC50=10 μM), and no activity as inhibitors of FAAH in N18TG2 cell membranes (Ki>50 μM)[1].
References	[1]. Ortar G, et al. Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochem Pharmacol. 2003 May 1;65(9):1473-81.