58002-62-3

58002-62-3 structure
58002-62-3 structure
  • Name: Kainic acid hydrate
  • Chemical Name: (−)-(α)-Kainic Acid
  • CAS Number: 58002-62-3
  • Molecular Formula: C10H15NO4
  • Molecular Weight: 213.230
  • Catalog: Biochemical Common amino acids and protein drugs
  • Create Date: 2018-08-21 17:41:40
  • Modify Date: 2024-01-02 17:01:26
  • Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures[1][2].

Name (−)-(α)-Kainic Acid
Synonyms kainic acid
MFCD00150833
(3S,4S)-3-(Carboxymethyl)-4-isopropenyl-L-proline
(−)-Kainic Acid
L-Proline, 3-(carboxymethyl)-4-(1-methylethenyl)-, (3S,4S)-
Description Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures[1][2].
Related Catalog
In Vivo Kainic acid hydrate (5 mg/kg;腹腔注射;每小时一次至少 3 小时,直至癫痫持续状态) 诱导大鼠癫痫发作[1]。 Animal Model: 8 weeks, 200-250 g male adult Wistar rats[1] Dosage: 5 mg/kg Administration: I.p.; hourly at least 3 h until status epilepticus Result: Induced seizures in rats.
References

[1]. Cincioğlu-Palabiyik M, et al. Chronic levetiracetam decreases hippocampal and testicular aromatase expression in normal but not kainic acid-induced experimental model of acute seizures in rats. Neuroreport. 2017 Sep 27;28(14):903-909.  

[2]. Wang Q, et al. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol Neurobiol. 2005;31(1-3):3-16.  

Density 1.2±0.1 g/cm3
Boiling Point 439.9±45.0 °C at 760 mmHg
Melting Point 250-252°C
Molecular Formula C10H15NO4
Molecular Weight 213.230
Flash Point 219.8±28.7 °C
Exact Mass 213.100113
LogP 0.50
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.509
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22;S24/25
RIDADR NONH for all modes of transport
WGK Germany 3