1359825-94-7

1359825-94-7 structure

Name: RTC13
Chemical Name: RTC13
CAS Number: 1359825-94-7
Molecular Formula: C₁₄H₉N₃O₄S
Molecular Weight: 315.30
Create Date: 2018-10-16 09:13:33
Modify Date: 2024-01-02 11:27:51
RTC13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy (DMD)[1].

Name	RTC13
Synonyms	(5Z)-2-Amino-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-4(5H)-thiazolone (Z)-2-amino-5-((5-(2-nitrophenyl)furan-2-yl)methylene)thiazol-4(5H)-one 4(5H)-Thiazolone, 2-amino-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-, (5Z)-

Description	RTC13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy (DMD)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vivo	Animal Model: Wild-type (C57BL/10) mice at 10 to 12 weeks of age[1]. Dosage: 10 (n = 5), 30 (n = 5), 60 (n = 5) or 300 mg/kg (n = 5). Administration: Intraperitoneal Administration. Result: No changes were observed in liver and kidney weights at the time of necropsies, and Hematoxylin and Eosin (H&E) staining revealed the absence of histopathological changes.
References	[1]. Refik Kayali, et al. Read-through compound 13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy. Hum Mol Genet. 2012 Sep 15;21(18):4007-20.