1000026-77-6

1000026-77-6 structure

Name: sinomenine N-oxide
Chemical Name: sinomenine N-oxide
CAS Number: 1000026-77-6
Molecular Formula: C₁₉H₂₃NO₅
Molecular Weight: 345.39
Create Date: 2018-03-31 21:48:23
Modify Date: 2025-08-26 08:18:25
Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC50 value of 23.04 μM[1][2][3].

Name	sinomenine N-oxide
Synonyms	sinomenine-N-oxide

Description	Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC50 value of 23.04 μM[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Sinomenine N-oxide (10-200 μM, 2 h) 抑制 LPS 诱导的 Raw264.7 细胞中的 IL-6 和 TNF-α 水平[3]。
References	[1]. Liu WJ, et al. Network pharmacology approach to elucidate possible action mechanisms of Sinomenii Caulis for treating osteoporosis. J Ethnopharmacol. 2020 Jul 15;257:112871. [2]. Zeng HL, et al. New N-oxide alkaloids from the stems of Sinomenium acutum. Fitoterapia. 2023 Mar;165:105404. [3]. Li Q, et al. Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide. Life Sci. 2020 Nov 15;261:118433.