181041-62-3

181041-62-3 structure

Name: (2R)-2,3-Bis[(2H31)hexadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate
Chemical Name: (2R)-2,3-Bis[(2H31)hexadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate
CAS Number: 181041-62-3
Molecular Formula: C₄₀H₅D₇₅NO₈P
Molecular Weight: 809.501
Catalog: Research Areas Others
Create Date: 2018-01-23 05:57:07
Modify Date: 2024-01-26 21:15:55
DPPC-d75 is deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in

Name	(2R)-2,3-Bis[(2H31)hexadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate
Synonyms	Ethan-1,1,2,2-d-aminium, 2-[[[(2R)-2,3-bis[(1-oxohexadecyl-2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d)oxy]propoxy]hydroxyphosphinyl]oxy]-N,N,N-tri(methyl-d)-, inner salt (2R)-2,3-Bis[(H)hexadecanoyloxy]propyl 2-{tris[(H)methyl]ammonio}(H)ethyl phosphate

Description	DPPC-d75 is deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in
Related Catalog	Research Areas >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].
References	[1]. Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811. [2]. Akiko Uemura, et al. Induction of immune responses against glycosphingolipid antigens: comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipids. J Vet Med Sci. 2005 Dec;67(12):1197-201. [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.