(2R)-2,3-Bis[(2H31)hexadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate

Modify Date: 2024-01-26 21:15:55

(2R)-2,3-Bis[(2H31)hexadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate Structure
(2R)-2,3-Bis[(2H31)hexadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate structure
Common Name (2R)-2,3-Bis[(2H31)hexadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate
CAS Number 181041-62-3 Molecular Weight 809.501
Density N/A Boiling Point N/A
Molecular Formula C40H5D75NO8P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (2R)-2,3-Bis[(2H31)hexadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate


DPPC-d75 is deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in

 Names

Name (2R)-2,3-Bis[(2H31)hexadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate
Synonym More Synonyms

  Biological Activity

Description DPPC-d75 is deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].
References

[1]. Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.

[2]. Akiko Uemura, et al. Induction of immune responses against glycosphingolipid antigens: comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipids. J Vet Med Sci. 2005 Dec;67(12):1197-201.

[3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

 Chemical & Physical Properties

Molecular Formula C40H5D75NO8P
Molecular Weight 809.501
Exact Mass 809.032898
LogP 10.88

 Synonyms

Ethan-1,1,2,2-d-aminium, 2-[[[(2R)-2,3-bis[(1-oxohexadecyl-2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d)oxy]propoxy]hydroxyphosphinyl]oxy]-N,N,N-tri(methyl-d)-, inner salt
(2R)-2,3-Bis[(H)hexadecanoyloxy]propyl 2-{tris[(H)methyl]ammonio}(H)ethyl phosphate