212116-78-4

212116-78-4 structure

Name: C16 PEG2 CERAMIDE
Chemical Name: (4E)-3-Hydroxy-2-(palmitoylamino)-4-octadecen-1-yl 2-methoxyethyl succinate
CAS Number: 212116-78-4
Molecular Formula: C₄₁H₇₇NO₇
Molecular Weight: 696.053
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-05-07 22:01:33
Modify Date: 2023-01-20 18:46:59
C16 PEG-Ceramide is a polyethylene glycolylated ceramide. C16 PEG-Ceramide can be used for lipid carrier to delivery. C16 PEG-Ceramide induces autophagy. C16 PEG-Ceramide can be used for cancer research[1][2].

Name	(4E)-3-Hydroxy-2-(palmitoylamino)-4-octadecen-1-yl 2-methoxyethyl succinate
Synonyms	(4E)-3-Hydroxy-2-(palmitoylamino)-4-octadecen-1-yl 2-methoxyethyl succinate Butanedioic acid, (4E)-3-hydroxy-2-[(1-oxohexadecyl)amino]-4-octadecen-1-yl 2-methoxyethyl ester

Description	C16 PEG-Ceramide is a polyethylene glycolylated ceramide. C16 PEG-Ceramide can be used for lipid carrier to delivery. C16 PEG-Ceramide induces autophagy. C16 PEG-Ceramide can be used for cancer research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
In Vitro	C16 PEG-Ceramide (0-118.6μM, 24 hours) has cytotoxicity and promotes autophagy in N2a cells[2]. Cell Cytotoxicity Assay[2]. Cell Line: N2a cells Concentration: 3.7-118.6 μM Incubation Time: 24 hours Result: Inhibits N2a cells activity in a dose-dependent. Western Blot Analysis[2]. Cell Line: N2a cells Concentration: 2.5, 5.0, 10 and 20 μM Incubation Time: 24 hours Result: Increased the LC3-II/LC3-I ratios, reduced the content of WT-Tau and P301L-Tau proteins in the cells.
References	[1]. Su X, et, al. Co-delivery of doxorubicin and PEGylated C16-ceramide by nanoliposomes for enhanced therapy against multidrug resistance. Nanomedicine (Lond). 2015;10(13):2033-50. [2]. Gao J, et, al. PEG-Ceramide Nanomicelles Induce Autophagy and Degrade Tau Proteins in N2a Cells. Int J Nanomedicine. 2020 Sep 11;15:6779-6789.