159190-44-0

159190-44-0 structure

Name: L-NIO dihydrochloride
Chemical Name: (E)-N5-(1-Aminoethylidene)-L-ornithine dihydrochloride
CAS Number: 159190-44-0
Molecular Formula: C₇H₁₇Cl₂N₃O₂
Molecular Weight: 246.135
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-06-14 08:55:34
Modify Date: 2024-01-09 18:50:01
L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats[2].

Name	(E)-N5-(1-Aminoethylidene)-L-ornithine dihydrochloride
Synonyms	(E)-N-(1-Aminoethylidene)-L-ornithine dihydrochloride L-Ornithine, N-(1-aminoethylidene)-, (E)-, hydrochloride (1:2)

Description	L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats[2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Target	Ki: 1.7 μM (nNOS), 3.9 μM (eNOS), 3.9 μM (iNOS)[1]
References	[1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9. [2]. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57.