L-NIO dihydrochloride

Modify Date: 2024-01-09 18:50:01

L-NIO dihydrochloride Structure
L-NIO dihydrochloride structure
 Common Name L-NIO dihydrochloride
CAS Number 159190-44-0 Molecular Weight 246.135
Density N/A Boiling Point N/A
Molecular Formula C7H17Cl2N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of L-NIO dihydrochloride


L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats[2].

 Names

Name (E)-N5-(1-Aminoethylidene)-L-ornithine dihydrochloride
Synonym More Synonyms

 L-NIO dihydrochloride Biological Activity

Description L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats[2].
Related Catalog
Target

Ki: 1.7 μM (nNOS), 3.9 μM (eNOS), 3.9 μM (iNOS)[1]

References

[1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9.

[2]. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57.

 Chemical & Physical Properties

Molecular Formula C7H17Cl2N3O2
Molecular Weight 246.135
Exact Mass 245.069778
Appearance of Characters NA
Storage condition 2-8℃

 Safety Information

 Synonyms

(E)-N-(1-Aminoethylidene)-L-ornithine dihydrochloride
L-Ornithine, N-(1-aminoethylidene)-, (E)-, hydrochloride (1:2)
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