86088-83-7

86088-83-7 structure

Name: Fibronectin
Chemical Name: Fibronectin from bovine plasma
CAS Number: 86088-83-7
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2018-12-23 17:14:30
Modify Date: 2024-01-09 11:42:16
Fibronectin, a glycoprotein (~500 kDa) present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans[1].

Name	Fibronectin from bovine plasma
Synonyms	EINECS 289-149-2 MFCD00131062

Description	Fibronectin, a glycoprotein (~500 kDa) present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Cytoskeleton >> Integrin
In Vitro	Fibronectin (FN) is a glycoprotein present in blood as well as in cells. While Fibronectin (FN) in blood has many functions, its primary role is to promote wound repair following injury. Increases in plasma Fibronectin (FN) has been reported after inflammation, trauma, and diseases such as atherosclerosis. Tobacco-related lung diseases are characterized by increased accumulation of Fibronectin (FN) which can be induced by nicotine. We found significant increases of plasma Fibronectin (FN) following exposure to e-cig aerosols and TS. Although our study examined the levels of 8-oxodG, CRP, and Fibronectin (FN), additional markers for lung injury need be explored in future studies[1]. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans) [2].
References	[1]. Yuan-Wan Sun, et al. Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice. Chem Res Toxicol. 2021 Apr 19;34(4):1161-1168. [2]. Roumen Pankov, et al. Fibronectin at a glance. J Cell Sci. 2002 Oct 15;115(Pt 20):3861-3.

Storage condition	-20C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

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