113-69-9

113-69-9 structure

Name: Benzquinamide hydrochloride
Chemical Name: 3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride
CAS Number: 113-69-9
Molecular Formula: C₂₂H₃₃ClN₂O₅
Molecular Weight: 440.96
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-12-23 19:15:40
Modify Date: 2024-01-04 23:23:00
Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively. Benzquinamide also inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells[1][2].

Name	3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride
Synonyms	EINECS 204-033-3

Description	Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively. Benzquinamide also inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	Ki: 1,365, 691, and 545 nM (α2A, α2B,α2C receptor)[1]
References	[1]. Elisabet Gregori-Puigjané, et al. Identifying mechanism-of-action targets for drugs and probes. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28): 11178-11183. [2]. Mazzanti R, et al. Benzquinamide inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells. Oncol Res. 1992;4(8-9):359-65.

Molecular Formula	C₂₂H₃₃ClN₂O₅
Molecular Weight	440.96