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205640-91-1

205640-91-1 structure

205640-91-1 structure

Name: Orexin B (human) trifluoroacetate salt
Chemical Name: Orexin B(human)
CAS Number: 205640-91-1
Molecular Formula: C₁₂₃H₂₁₂N₄₄O₃₅S
Molecular Weight: 2899.338
Catalog: Biochemical Peptide
Create Date: 2018-03-02 08:00:00
Modify Date: 2026-06-30 14:15:03
Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.

Name	Orexin B(human)
Synonyms	HYPOCRETIN-2 L-Methioninamide, L-ginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-ginyl-L-leucyl-L-glutaminyl-L-ginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-aspaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl Orexin B (human) (trifluoroacetate salt) RSGPPGLQLQRLLQASGNHAAGILTM-NH2 L-Arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide OREXIN B (HUMAN) //BP OREXINS OREXIN B HUMAN OREXIN B HUMAN Human orexin B G-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-G-LEU-GLN-G-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2 H-G-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-G-LEU-GLN-G-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2 Orexin A/B 5mg (human) RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 HYPOCRETIN-2, HUMAN Orexin B（Human）（Leu* U-13C6,15N） OREXIN B (HUMAN) REF DUPL: g-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-g-Leu-Gln-g-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 Orexin B, human PubChem ID Orexin B (human), (HPLC) Orexin B (huMan) Hypocretin-2 (huMan)

Description	Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Orexin Receptor (OX Receptor) Peptides Research Areas >> Neurological Disease
Target	Ki: 420 nM (OX1), 36 nM (OX2)[1]
In Vitro	Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2].
In Vivo	Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively[2].
Animal Admin	Rats[2] 3 nM and 30 nM of synthetic human Orexin B is administered in a 5 mL bolus through a catheter placed in the left lateral ventricle of Male Wistar rats (180–200 g) in early light phase. Cumulative food consumption is observed and plotted over the period of 4 hr after injection[2].
References	[1]. Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. [2]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85.

Density	1.5±0.1 g/cm3
Molecular Formula	C₁₂₃H₂₁₂N₄₄O₃₅S
Molecular Weight	2899.338
Exact Mass	2897.588135
LogP	-9.29
Index of Refraction	1.665
Storage condition	−20°C

WGK Germany	3

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