462605-73-8

462605-73-8 structure

Name: Adhesamine
Chemical Name: Adhesamine
CAS Number: 462605-73-8
Molecular Formula: C₂₄H₃₂Cl₄N₈O₂S₂
Molecular Weight: 670.505
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FAK
Create Date: 2018-02-28 08:00:00
Modify Date: 2024-01-13 17:56:48
Adhesamine, dumbbell-shaped molecule, activates MAPK/FAK pathway. Adhesamine promotes adhesion and growth of mammalian cells. Adhesamine accelerates the differentiation and improves the survival of mice hippocampal neurons in primary culture[1].

Name	Adhesamine
Synonyms	3,12-Bis[6-chloro-5-formyl-2-(methylsulfanyl)-4-pyrimidinyl]-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane dichloride 3,12-Diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane, 3,12-bis[6-chloro-5-formyl-2-(methylthio)-4-pyrimidinyl]-, chloride (1:2)

Description	Adhesamine, dumbbell-shaped molecule, activates MAPK/FAK pathway. Adhesamine promotes adhesion and growth of mammalian cells. Adhesamine accelerates the differentiation and improves the survival of mice hippocampal neurons in primary culture[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK Research Areas >> Neurological Disease
Target	MAPK/FAK[1]
In Vitro	Adhesamine (20 μg/mL; 0-30 d) 促进小鼠原代培养海马神经元的附着并提高其存活率。Adhesamine 还诱导小鼠原代培养海马神经元神经突分支和快速分化[1]。 Adhesamine (20 μg/mL; 1 d, 3 d, 4 d) 细胞表面硫酸肝素诱导细胞粘附并激活 FAK 磷酸化。Adhesamine 还通过 MAPK 激活刺激神经突分化[1]。
References	[1]. Hoshino M, et al. Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons. Biochem J. 2010 Mar 29;427(2):297-304.