Adhesamine

Modify Date: 2024-01-13 17:56:48

Adhesamine Structure
Adhesamine structure
Common Name Adhesamine
CAS Number 462605-73-8 Molecular Weight 670.505
Density N/A Boiling Point N/A
Molecular Formula C24H32Cl4N8O2S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Adhesamine


Adhesamine, dumbbell-shaped molecule, activates MAPK/FAK pathway. Adhesamine promotes adhesion and growth of mammalian cells. Adhesamine accelerates the differentiation and improves the survival of mice hippocampal neurons in primary culture[1].

 Names

Name Adhesamine
Synonym More Synonyms

 Adhesamine Biological Activity

Description Adhesamine, dumbbell-shaped molecule, activates MAPK/FAK pathway. Adhesamine promotes adhesion and growth of mammalian cells. Adhesamine accelerates the differentiation and improves the survival of mice hippocampal neurons in primary culture[1].
Related Catalog
Target

MAPK/FAK[1]

In Vitro Adhesamine (20 μg/mL; 0-30 d) 促进小鼠原代培养海马神经元的附着并提高其存活率。Adhesamine 还诱导小鼠原代培养海马神经元神经突分支和快速分化[1]。 Adhesamine (20 μg/mL; 1 d, 3 d, 4 d) 细胞表面硫酸肝素诱导细胞粘附并激活 FAK 磷酸化。Adhesamine 还通过 MAPK 激活刺激神经突分化[1]。
References

[1]. Hoshino M, et al. Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons. Biochem J. 2010 Mar 29;427(2):297-304.  

 Chemical & Physical Properties

Molecular Formula C24H32Cl4N8O2S2
Molecular Weight 670.505
Exact Mass 668.084351

 Synonyms

3,12-Bis[6-chloro-5-formyl-2-(methylsulfanyl)-4-pyrimidinyl]-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane dichloride
3,12-Diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane, 3,12-bis[6-chloro-5-formyl-2-(methylthio)-4-pyrimidinyl]-, chloride (1:2)
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