GL Biochem (Shanghai) Ltd.
China
Product Name: Pancreatic Polypeptide (human)
Price: $Inquiry/1g
Purity: 98.0%
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Contact: Jackie Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Pancreatic Polypeptide (human) trifluoroacetate salt
Price: ￥Inquiry/1mg ￥2118.0/1mg ￥Inquiry/1mg
Purity: 95.0%
Stocking Period: Inquiry
Contact: Liu jia

Zhejiang Hangyu API Co., Ltd
China
Product Name: Pancreatic Polypeptide, human
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

75976-10-2

75976-10-2 structure

75976-10-2 structure

Name: Pancreatic Polypeptide (human) trifluoroacetate salt
Chemical Name: Pancreatic Polypeptide(Human)
CAS Number: 75976-10-2
Molecular Formula: C₁₈₅H₂₈₇N₅₃O₅₄S₂
Molecular Weight: 4181.71
Catalog: Biochemical Peptide
Create Date: 2018-04-21 08:00:00
Modify Date: 2024-01-10 12:44:03
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

Name	Pancreatic Polypeptide(Human)
Synonyms	MFCD00081812 Pancreatic Polypeptide (human) Pancreatic Polypeptide, human

Description	Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor Research Areas >> Metabolic Disease Peptides
Target	Neuropeptide Y (NPY) Y4/Y5 receptor[1]
In Vitro	Human pancreatic polypeptide (hPP) is one such peptide, being released postprandially from F cells of the pancreatic islets depending on caloric load, food consumption and circadian rhythm. It is a C-terminally amidated 36 amino acid peptide with a characteristic hairpin-like pancreatic polypeptide (PP)-fold and acts at the Y4 receptor to induce satiety and delay gastric emptying and motility[1]. Addition of the human pancreatic polypeptide (hPP) (10 nM-1 μM) results in a significant, dose-dependent reduction in both basal and stimulated release. Human pancreatic polypeptide (hPP) can also inhibit basal and stimulated NPY release with a pharmacological profile suggesting a role for Y4 presynaptic receptors[2].
References	[1]. Thieme V, et al. High molecular weight PEGylation of human pancreatic polypeptide at position 22 improvesstability and reduces food intake in mice. Br J Pharmacol. 2016 Nov;173(22):3208-3221. [2]. King PJ, et al. Regulation of neuropeptide Y release by neuropeptide Y receptor ligands and calcium channel antagonists in hypothalamic slices. J Neurochem. 1999 Aug;73(2):641-6.

Molecular Formula	C₁₈₅H₂₈₇N₅₃O₅₄S₂
Molecular Weight	4181.71
Storage condition	-15°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport