537672-41-6

537672-41-6 structure

Name: UF010
Chemical Name: 4-Bromo-N'-butylbenzohydrazide
CAS Number: 537672-41-6
Molecular Formula: C₁₁H₁₅BrN₂O
Molecular Weight: 271.154
Catalog: Research Areas Cancer
Create Date: 2018-04-15 12:35:36
Modify Date: 2024-01-29 09:44:33
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.IC50 value: 0.06 μM (HDAC3), 0.1 μM (HDAC2), 0.5 μM (HDAC1), 1.5 μM(HDAC 8)Target: HDACin vitro: UF010 is a competitive inhibitor with a fast-on/slow-off HDAC-binding mechanism. UF010 induces accumulation of acetylated histones in HCT116 cells in vitro, arrests cells at G1/S transition. It inhibits proliferation of a range of cancer cell lines. UF010 activates tumor suppression mechanisms while inhibiting oncogenic pathways.

Name	4-Bromo-N'-butylbenzohydrazide
Synonyms	4-Bromo-N'-butylbenzohydrazide Benzoic acid, 4-bromo-, 2-butylhydrazide UF010

Description	UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.IC50 value: 0.06 μM (HDAC3), 0.1 μM (HDAC2), 0.5 μM (HDAC1), 1.5 μM(HDAC 8)Target: HDACin vitro: UF010 is a competitive inhibitor with a fast-on/slow-off HDAC-binding mechanism. UF010 induces accumulation of acetylated histones in HCT116 cells in vitro, arrests cells at G1/S transition. It inhibits proliferation of a range of cancer cell lines. UF010 activates tumor suppression mechanisms while inhibiting oncogenic pathways.
Related Catalog	Research Areas >> Cancer
Target	HDAC3:0.06 μM (IC50) HDAC2:0.1 μM (IC50) HDAC1:0.5 μM (IC50) HDAC8:1.5 μM (IC50) HDAC6:9.1 μM (IC50) HDAC10:15.3 μM (IC50) HDAC11:44.5 μM (IC50)
References	[1]. Wang Y, et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol. 2015 Feb 19;22(2):273-284.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport