1008763-54-9
1008763-54-9 structure
- Name: D-3263 (hydrochloride)
- Chemical Name: 3-(2-Aminoethyl)-1-{[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]carbonyl}-5-methoxy-1,3-dihydro-2H-benzimidazol-2-one hydrochloride (1:1)
- CAS Number: 1008763-54-9
- Molecular Formula: C21H32ClN3O3
- Molecular Weight: 409.950
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2018-03-28 12:49:44
- Modify Date: 2024-01-08 01:50:33
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D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.
| Name | 3-(2-Aminoethyl)-1-{[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]carbonyl}-5-methoxy-1,3-dihydro-2H-benzimidazol-2-one hydrochloride (1:1) |
|---|---|
| Synonyms |
2H-Benzimidazol-2-one, 3-(2-aminoethyl)-1,3-dihydro-5-methoxy-1-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]carbonyl]-, hydrochloride (1:1)
3-(2-Aminoethyl)-1-{[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]carbonyl}-5-methoxy-1,3-dihydro-2H-benzimidazol-2-one hydrochloride (1:1) D-3263 HCl D-3263 (hydrochloride) |
| Description | D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist. |
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| Related Catalog | |
| In Vitro | D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. D-3263 hydrochloride may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH[1]. |
| References |
| Molecular Formula | C21H32ClN3O3 |
|---|---|
| Molecular Weight | 409.950 |
| Exact Mass | 409.213226 |
| Storage condition | 2-8℃ |