1627710-50-2

1627710-50-2 structure

Name: LJH-685
Chemical Name: 2,6-Difluoro-4-{4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl}phenol
CAS Number: 1627710-50-2
Molecular Formula: C₂₂H₂₁F₂N₃O
Molecular Weight: 381.418
Catalog: Signaling Pathways MAPK/ERK Pathway Ribosomal S6 Kinase (RSK)
Create Date: 2018-05-15 01:01:49
Modify Date: 2024-01-09 14:07:00
LJH685 is a potent , specific and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50 of 4 to 13 nM.IC50 value: 4 to 13 nM [1]Target: RSKin vitro: LJH685 efficiently inhibits RSK activity in cells. LJH685 RSK inhibition correlates with antiproliferative effects in MAPK pathway-dependent cancer cell lines only in anchorage-independent growth setting. The EC 50 values of LJH685 is 0.73 and 0.79 μM in MDA-MB-231 and H358. [1]

Name	2,6-Difluoro-4-{4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl}phenol
Synonyms	Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]- 2,6-Difluoro-4-{4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl}phenol LJH-685 LJH685

Description	LJH685 is a potent , specific and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50 of 4 to 13 nM.IC50 value: 4 to 13 nM [1]Target: RSKin vitro: LJH685 efficiently inhibits RSK activity in cells. LJH685 RSK inhibition correlates with antiproliferative effects in MAPK pathway-dependent cancer cell lines only in anchorage-independent growth setting. The EC 50 values of LJH685 is 0.73 and 0.79 μM in MDA-MB-231 and H358. [1]
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK) Research Areas >> Cancer
References	[1]. Aronchik I, et al. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol Cancer Res. 2014 May;12(5):803-12. [2]. Davies AH, et al. Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells. Oncotarget. 2015 Aug 21;6(24):20570-7. [3]. Jain R, et al. Discovery of Potent and Selective RSK Inhibitors as Biological Probes. J Med Chem. 2015 Sep 10;58(17):6766-83.