LJH-685
Modify Date: 2024-01-09 14:07:00
LJH-685 structure
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Common Name | LJH-685 | ||
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| CAS Number | 1627710-50-2 | Molecular Weight | 381.418 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 481.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C22H21F2N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 244.7±28.7 °C | |
Use of LJH-685LJH685 is a potent , specific and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50 of 4 to 13 nM.IC50 value: 4 to 13 nM [1]Target: RSKin vitro: LJH685 efficiently inhibits RSK activity in cells. LJH685 RSK inhibition correlates with antiproliferative effects in MAPK pathway-dependent cancer cell lines only in anchorage-independent growth setting. The EC 50 values of LJH685 is 0.73 and 0.79 μM in MDA-MB-231 and H358. [1] |
| Name | 2,6-Difluoro-4-{4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl}phenol |
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| Synonym | More Synonyms |
| Description | LJH685 is a potent , specific and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50 of 4 to 13 nM.IC50 value: 4 to 13 nM [1]Target: RSKin vitro: LJH685 efficiently inhibits RSK activity in cells. LJH685 RSK inhibition correlates with antiproliferative effects in MAPK pathway-dependent cancer cell lines only in anchorage-independent growth setting. The EC 50 values of LJH685 is 0.73 and 0.79 μM in MDA-MB-231 and H358. [1] |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 481.1±45.0 °C at 760 mmHg |
| Molecular Formula | C22H21F2N3O |
| Molecular Weight | 381.418 |
| Flash Point | 244.7±28.7 °C |
| Exact Mass | 381.165283 |
| LogP | 3.31 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.601 |
| Storage condition | -20℃ |
| Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]- |
| 2,6-Difluoro-4-{4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl}phenol |
| LJH-685 |
| LJH685 |