329059-55-4
329059-55-4 structure
- Name: BRD7116
- Chemical Name: N,N'-(Sulfonyldi-4,1-phenylene)bis(2,2,3,3-tetramethylcyclopropanecarboxamide)
- CAS Number: 329059-55-4
- Molecular Formula: C28H36N2O4S
- Molecular Weight: 496.661
- Catalog: Research Areas Others
- Create Date: 2018-05-13 06:23:11
- Modify Date: 2024-02-22 10:09:54
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BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity.IC50 value: 200 nM (EC50, for LSCe cells)Target: DNA gyraseBRD7116 is a bis-aryl sulfone, shows evidence of stroma-mediated anti-LSCe activity. BRD7116 exhibits an EC50 of 200 nM for LSCe cells in co-culture, whereas it displays limited activity against normal HSPCs and AML cell lines (~50% inhibition at 20 μM). BRD7116 also shows activity against patient-derived, primary human leukemia cells. [1] BRD7116 inhibits LSCs via non-cell-autonomous effects on stromal cells as well as cell-autonomous induction of myeloid differentiation genes in LSCs.
| Name | N,N'-(Sulfonyldi-4,1-phenylene)bis(2,2,3,3-tetramethylcyclopropanecarboxamide) |
|---|---|
| Synonyms |
Cyclopropanecarboxamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-
N,N'-(Sulfonyldi-4,1-phenylene)bis(2,2,3,3-tetramethylcyclopropanecarboxamide) BRD7116 |
| Description | BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity.IC50 value: 200 nM (EC50, for LSCe cells)Target: DNA gyraseBRD7116 is a bis-aryl sulfone, shows evidence of stroma-mediated anti-LSCe activity. BRD7116 exhibits an EC50 of 200 nM for LSCe cells in co-culture, whereas it displays limited activity against normal HSPCs and AML cell lines (~50% inhibition at 20 μM). BRD7116 also shows activity against patient-derived, primary human leukemia cells. [1] BRD7116 inhibits LSCs via non-cell-autonomous effects on stromal cells as well as cell-autonomous induction of myeloid differentiation genes in LSCs. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 681.1±40.0 °C at 760 mmHg |
| Molecular Formula | C28H36N2O4S |
| Molecular Weight | 496.661 |
| Flash Point | 365.7±27.3 °C |
| Exact Mass | 496.239563 |
| LogP | 6.40 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.576 |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
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