BRD7116
Modify Date: 2024-02-22 10:09:54
BRD7116 structure
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Common Name | BRD7116 | ||
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| CAS Number | 329059-55-4 | Molecular Weight | 496.661 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 681.1±40.0 °C at 760 mmHg | |
| Molecular Formula | C28H36N2O4S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 365.7±27.3 °C | |
Use of BRD7116BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity.IC50 value: 200 nM (EC50, for LSCe cells)Target: DNA gyraseBRD7116 is a bis-aryl sulfone, shows evidence of stroma-mediated anti-LSCe activity. BRD7116 exhibits an EC50 of 200 nM for LSCe cells in co-culture, whereas it displays limited activity against normal HSPCs and AML cell lines (~50% inhibition at 20 μM). BRD7116 also shows activity against patient-derived, primary human leukemia cells. [1] BRD7116 inhibits LSCs via non-cell-autonomous effects on stromal cells as well as cell-autonomous induction of myeloid differentiation genes in LSCs. |
| Name | N,N'-(Sulfonyldi-4,1-phenylene)bis(2,2,3,3-tetramethylcyclopropanecarboxamide) |
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| Synonym | More Synonyms |
| Description | BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity.IC50 value: 200 nM (EC50, for LSCe cells)Target: DNA gyraseBRD7116 is a bis-aryl sulfone, shows evidence of stroma-mediated anti-LSCe activity. BRD7116 exhibits an EC50 of 200 nM for LSCe cells in co-culture, whereas it displays limited activity against normal HSPCs and AML cell lines (~50% inhibition at 20 μM). BRD7116 also shows activity against patient-derived, primary human leukemia cells. [1] BRD7116 inhibits LSCs via non-cell-autonomous effects on stromal cells as well as cell-autonomous induction of myeloid differentiation genes in LSCs. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 681.1±40.0 °C at 760 mmHg |
| Molecular Formula | C28H36N2O4S |
| Molecular Weight | 496.661 |
| Flash Point | 365.7±27.3 °C |
| Exact Mass | 496.239563 |
| LogP | 6.40 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.576 |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
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| Cyclopropanecarboxamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl- |
| N,N'-(Sulfonyldi-4,1-phenylene)bis(2,2,3,3-tetramethylcyclopropanecarboxamide) |
| BRD7116 |