1459687-89-8

1459687-89-8 structure

Name: GJ103
Chemical Name: GJ103
CAS Number: 1459687-89-8
Molecular Formula: C₁₆H₁₄N₄O₃S
Molecular Weight: 342.378
Catalog: Research Areas Cancer
Create Date: 2018-07-28 22:13:15
Modify Date: 2024-02-05 09:18:27
GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations[1].

Name	GJ103
Synonyms	2-(4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid

Description	GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vivo	GJ103 (10-30 μM; 4 days) 在具有纯合 TGA 突变和纯合 TAA 突变的 AT153LA 细胞中诱导 ATM 激酶活性[1]。 GJ103 在浓度高达 300 µM 时对 A-T 细胞没有表现出明显的细胞毒性[1]。
References	[1]. Du L, et, al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60.