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  • DC Chemicals Limited
  • China
  • Product Name: MELK-8a
  • Price: $550.0/100mg $900.0/250mg $1800.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1922153-17-0

1922153-17-0 structure
1922153-17-0 structure
  • Name: MELK-8a
  • Chemical Name: MELK-8a
  • CAS Number: 1922153-17-0
  • Molecular Formula: C25H32N6O
  • Molecular Weight: 432.572
  • Catalog: Signaling Pathways PI3K/Akt/mTOR MELK
  • Create Date: 2018-05-16 17:58:20
  • Modify Date: 2024-01-31 13:14:40
  • MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells[1].

Name MELK-8a
Synonyms 1-methyl-4-[4-[4-[3-(piperidin-4-ylmethoxy)pyridin-4-yl]pyrazol-1-yl]phenyl]piperazine
Description MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells[1].
Related Catalog
References

[1]. B Barry Touré, et al. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J Med Chem. 2016 May 26;59(10):4711-23.

Molecular Formula C25H32N6O
Molecular Weight 432.572
Exact Mass 432.264